This systemic review utilized search terms such as Quality Adjusted Life Years (QALYs), cost-benefit and cost-effectiveness in specific relation to economic studies. Two studies both demonstrated that patients with spondylolisthesis treated with a surgical procedure had gains over non-operative treatment in terms of QALYs ranging from 0.0991 to 0.22 during a two-year horizon and one going on to further analyze at a four -year horizon showing a QALY of 0.34.