I had an ORIF with a volar fixed angle plate placed 2 days ago.  I am supposed to keep my wrist in a splint for 2 weeks before I am allowed to do anything.  Is this normal?  I would think that my muscles would waste away in that time.  

The protocol that your surgeon gave you sounds like the standard protocol– no movement for two weeks and no strengthening until week six.  A recent article has found it to be more beneficial, however, to begin passive motion fairly immediately and strengthening as soon as two weeks. This would be a good discussion to have with your surgeon.